Medications & Therapy
Drugs do not have the same effect in all patients. This is due to many factors including an individual´s genetic make-up.
In order to achieve optimal function, a drug needs to reach a certain concentration in the body and stay at this concentration for a given period of time. Correct dosing of a drug needs to take into account the speed at which it is degraded and eliminated by the body. Furthermore, it needs to be considered that some drugs (“prodrugs”) are only effective after activation by enzymes of the body. Enzymes metabolizing (inactivating and activating) drugs are encoded by specific genes. Variants of these genes influence the activity of the enzymes. This genetic variation is one of several reasons why efficacy and tolerance of drugs vary greatly between individuals. Genetic tests for variants affecting metabolism of drugs thus facilitate individualized medical treatment. This keeps un-wanted side-effects to a minimum. Individualized medication is greatly desirable given that only 25-60% of drugs act optimally at doses recommended by the manufacturer.
Genes involved in metabolism of given drugs are listed in pharma.sensor. PGS.box “Pharma” tests relevant genes.